Page 234 - MEGIN Book Of Abstracts - 2023

spread group differences were found in the beta band, Consultants of Nebraska, Omaha, NE, USA; Department of
with significant changes mostly occurring between the Physical Therapy, Nebraska Medicine, Omaha, NE, USA; Insti-
normal cognition and MCI groups. Moreover, bilateral tute for Human Neuroscience, Boys Town National Research
frontal and left-hemispheric regions were particularly Hospital, Boys Town, NE, USA; College of Medicine, University
affected in the other frequencies as cognitive decline of Nebraska Medical Center, Omaha, NE, USA. Electronic ad-
becomes more pronounced. Our results suggest that dress: [email protected]
MCI and PDD may be qualitatively distinct cognitive
phenotypes, and most dramatic changes seem to have ABSTRACT The sequelae of Parkinson's disease (PD)
happened when the PD brain shows mild cognitive includes both motor- and cognitive-related symptoms.
decline.NEW & NOTEWORTHY Can we better stage Although traditionally considered a subcortical disease,
cognitive decline in patients with Parkinson's disease there is increasing evidence that PD has a major impact
(PD)? Here, we provide evidence that mild cognitive on cortical function as well. Prior studies have reported
impairment, rather than being simply a milder form alterations in cortical neural function in patients with
of dementia, may be a qualitatively distinct phase in PD during movement, but to date such studies have
its development. We suggest that the most dramatic not examined whether the complexity of multicom-
neurophysiological changes may occur during the time ponent movements modulate these alterations. In this
the PD brain transitions from normal cognition to MCI, study, 23 patients with PD (medication "off" state) and
then compensatory changes further occur as the brain 27 matched healthy controls performed simple and
"switches" to a dementia state. complex finger tapping sequences during magneto-
encephalography (MEG), and the resulting MEG data
Keywords: Parkinson’s, beamforming, cognitive impair- were imaged to identify the cortical oscillatory dynam-
ment, magnetoencephalography, resting-state ics serving motor performance. The patients with PD
were significantly slower than controls at executing
Journal of neurophysiology (2022), Vol. 127, No. 1 the sequences overall, and both groups took longer
(34936515) (0 citations) to complete the complex sequences than the simple.
In terms of neural differences, patients also exhibited
weaker beta complexity-related effects in the right
Altered neural oscillations during complex medial frontal gyrus and weaker complexity-related
sequential movements in patients with Parkinson's alpha activity in the right posterior and inferior parietal
disease (2021) lobules, suggesting impaired motor sequence execu-
tion. Characterizing the cortical pathophysiology of PD
McCusker, Marie C; Wiesman, Alex I; Spooner, Rachel could inform current and future therapeutic interven-
K; Santamaria, Pamela M; McKune, Jennifer; Heinrichs- tions that address both motor and cognitive symptoms.
Graham, Elizabeth; Wilson, Tony W
Keywords: Alpha oscillations, Magnetoencephalography,
Institute for Human Neuroscience, Boys Town National Re- Motor complexity, Parietal cortex
search Hospital, Boys Town, NE, USA; Interdepartmental Neu-
roscience Program, Yale University School of Medicine, New NeuroImage. Clinical (2021), Vol. 32 (34911196) (2
Haven, CT, USA; College of Medicine, University of Nebraska citations)
Medical Center, Omaha, NE, USA; The Montreal Neurologi-
cal Institute, McGill University, Montreal, Canada; Institute
for Human Neuroscience, Boys Town National Research
Hospital, Boys Town, NE, USA; College of Medicine, University
of Nebraska Medical Center, Omaha, NE, USA; Institute of
Clinical Neuroscience and Medical Psychology, Heinrich-
Heine University Düsseldorf, Düsseldorf, Germany; Neurology

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