Page 232 - MEGIN Book Of Abstracts - 2023

Deep brain stimulation for parkinson's disease Magnetoencephalography detects phase-
induces spontaneous cortical hypersynchrony in amplitude coupling in Parkinson's disease (2022)
extended motor and cognitive networks (2022)
Tanaka, Masataka; Yanagisawa, Takufumi; Fukuma,
Wang, Maxwell B; Boring, Matthew J; Ward, Michael J; Ryohei; Tani, Naoki; Oshino, Satoru; Mihara, Masahito;
Richardson, R Mark; Ghuman, Avniel Singh Hattori, Noriaki; Kajiyama, Yuta; Hashimoto, Ryota;
Ikeda, Manabu; Mochizuki, Hideki; Kishima, Haruhiko
Machine Learning Department, Carnegie Mellon University,
Pittsburgh, PA 15213, USA; Department of Neurological Department of Neurosurgery, Osaka University Graduate
Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA; School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871,
Harvard Medical School, Boston, MA 02115, USA Japan; Department of Neuroinformatics, ATR Computational
Neuroscience Laboratories, 2-2-2 Hikaridai, Seika-cho, Kyoto,
ABSTRACT The mechanism of action of deep brain 619 0288, Japan. [email protected];
stimulation (DBS) to the basal ganglia for Parkinson's Department of Neurology, Osaka University Graduate School
disease remains unclear. Studies have shown that DBS of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan;
decreases pathological beta hypersynchrony between Department of Rehabilitation, Faculty of Medicine, Academic
the basal ganglia and motor cortex. However, little is Assembly, University of Toyama, Toyama, Japan; Molecular
known about DBS's effects on long range corticocorti- Research Center for Children's Mental Development, United
cal synchronization. Here, we use machine learning Graduate School of Child Development, Osaka University, 2-2
combined with graph theory to compare resting-state Yamadaoka, Suita, Osaka, 565-0871, Japan; Department of
cortical connectivity between the off and on-stimu- Psychiatry, Osaka University Graduate School of Medicine,
lation states and to healthy controls. We found that 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan
turning DBS on increased high beta and gamma band
synchrony (26 to 50 Hz) in a cortical circuit spanning ABSTRACT To characterize Parkinson's disease, ab-
the motor, occipitoparietal, middle temporal, and normal phase-amplitude coupling is assessed in the
prefrontal cortices. The synchrony in this network was cortico-basal circuit using invasive recordings. It is
greater in DBS on relative to both DBS off and con- unknown whether the same phenomenon might be
trols, with no significant difference between DBS off found in regions other than the cortico-basal ganglia
and controls. Turning DBS on also increased network circuit. We hypothesized that using magnetoencepha-
efficiency and strength and subnetwork modularity lography to assess phase-amplitude coupling in the
relative to both DBS off and controls in the beta and whole brain can characterize Parkinson's disease. We
gamma band. Thus, unlike DBS's subcortical normaliza- recorded resting-state magnetoencephalographic sig-
tion of pathological basal ganglia activity, it introduces nals in patients with Parkinson's disease and in healthy
greater synchrony relative to healthy controls in cortical age- and sex-matched participants. We compared
circuitry that includes both motor and non-motor sys- whole-brain signals from the two groups, evaluat-
tems. This increased high beta/gamma synchronization ing the power spectra of 3 frequency bands (alpha,
may reflect compensatory mechanisms related to DBS's 8-12 Hz; beta, 13-25 Hz; gamma, 50-100 Hz) and the
clinical benefits, as well as undesirable non-motor side coupling between gamma amplitude and alpha or
effects. beta phases. Patients with Parkinson's disease showed
significant beta-gamma phase-amplitude coupling that
Keywords: deep brain stimulation, functional connectivity, was widely distributed in the sensorimotor, occipital,
magnetoencephalography, parkinson’s disease, synchrony and temporal cortices; healthy participants showed
such coupling only in parts of the somatosensory and
Cerebral cortex (New York, N.Y.: 1991) (2022), Vol. 32, No. temporal cortices. Moreover, beta- and gamma-band
20 (35136991) (0 citations) power differed significantly between participants in
the two groups (P < 0.05). Finally, beta-gamma phase-

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