Page 237 - MEGIN Book Of Abstracts - 2023

Institute for Cognitive Neuroscience, HSE University, Moscow, Keywords: Action verb, Classification, Functional connec-
Russian Federation. Electronic address: [email protected] tivity, Magnetoencephalography (MEG), Morphosyntax,
Parkinson’s disease (PD)
ABSTRACT Parkinson's disease (PD) is a neurodegen-
erative disorder, well-known for its motor symptoms; NeuroImage. Clinical (2021), Vol. 32 (34455187) (4
however, it also adversely affects cognitive functions, citations)
including language, a highly important human ability.
PD pathology is associated, even in the early stage of
the disease, with alterations in the functional connec- Randomized controlled trial of neurologic
tivity within cortico-subcortical circuitry of the basal music therapy in Parkinson's disease: research
ganglia as well as within cortical networks. Here, we rehabilitation protocols for mechanistic and clinical
investigated functional cortical connectivity related to investigations (2021)
spoken language processing in early-stage PD patients.
We employed a patient-friendly passive attention-free Buard, Isabelle; Lattanzio, Lucas; Stewart, Rebekah;
paradigm to probe neurophysiological correlates of Thompson, Sarah; Sjoberg, Kristin; Hookstadt, Karen;
language processing in PD patients without con- Morrow, Meghan; Holden, Samantha K; Sillau, Stefan;
founds related to active attention and overt motor Thaut, Michael; Kluger, Benzi
responses. MEG data were recorded from a group of
newly diagnosed PD patients and age-matched healthy Department of Neurology, University of Colorado Denver,
controls who were passively presented with spoken Fitzsimons Building, Mailstop F548, 13001 E. 17th Place, R24-
word stimuli (action and abstract verbs, as well as 002, Aurora, CO, 80045, USA. Isabelle.Buard@CUAnschutz.
grammatically correct and incorrect inflectional forms) edu; Rehabilitative Rhythms, Aurora, CO, USA; University of
while focussing on watching a silent movie. For each Colorado Hospital, Aurora, CO, USA; Faculty of Music, Univer-
of the examined linguistic aspects, a logistic regression sity of Toronto, Toronto, Canada; Department of Neurology,
classifier was used to classify participants as either PD University of Rochester Medical Center, Rochester, NY, USA
patients or healthy controls based on functional con-
nectivity within the temporo-fronto-parietal cortical BACKGROUND Presently available medications and
language networks. Classification was successful for ac- surgical treatments for Parkinson's disease have limited
tion verbs (accuracy = 0.781, p-value = 0.003) and, with effects on fine motor problems and often leave patients
lower accuracy, for abstract verbs (accuracy = 0.688, with significant fine motor disability. Standard of care
p-value = 0.041) and incorrectly inflected forms (ac- occupational therapy (OT) yields low efficacy, potential-
curacy = 0.648, p-value = 0.021), but not for correctly ly due to a lack of standard protocols. Neurologic music
inflected forms (accuracy = 0.523, p-value = 0.384). Our therapy (NMT) techniques, especially rhythmic audi-
findings point to quantifiable differences in functional tory stimulation which relies on interaction between
connectivity within the cortical systems underpinning rhythm and movement, have shown to be effective in
language processing in newly diagnosed PD patients PD gait rehabilitation possibly through their reliance on
compared to healthy controls, which arise early, in the neural pathways that are not affected by PD. Therapeu-
absence of clinical evidence of deficits in cognitive or tic instrumental music performance (TIMP) is one other
general language functions. The techniques presented NMT technique that holds promise but which mode of
here may aid future work on establishing neurolinguis- action and efficacy has not been investigated in PD yet.
tic markers to objectively and noninvasively identify
functional changes in the brain's language networks METHODS One hundred PD participants will be
even before clinical symptoms emerge. randomly assigned to receive 15 sessions of either
TIMP with rhythm or TIMP without rhythm, standard
of care OT, or to be waitlisted (control) over 5 consecu-
tive weeks. Brain oscillatory responses will be collected

 ontents  Index 216
C