Page 241 - MEGIN Book Of Abstracts - 2023

but not placebo, was a function of GABA concentration. Netherlands; Department of Humanistic Studies, University of
The study provides proof-of-concept for the potential Naples Federico II, via Porta di Massa 1, 80133, Naples, Italy;
of dynamic causal modelling to elucidate mechanisms Priority Research Centre for Brain and Mind, The University
of human neurodegenerative disease, and explains the of Newcastle, Medical Sciences, University Drive, Callaghan,
variation in response to candidate therapies among NSW, 2308, Australia; The Turner Institute for Brain and Men-
patients. The laminar- and neurotransmitter-specific tal Health, School of Psychological Sciences, and Monash
features of the modelling framework, can be used to Biomedical Imaging, Monash University, Clayton, VIC, Austra-
study other treatment approaches and disorders. In lia; Hermitage-Capodimonte Hospital, via Cupa delle Tozzole
the context of frontotemporal lobar degeneration, we 2, Naples, Italy
suggest that neurophysiological restoration in selected
patients, by targeting neurotransmitter deficits, could ABSTRACT Rapid reconfigurations of brain activity
be used to bridge between clinical and preclinical mod- support efficient neuronal communication and flexible
els of disease, and inform the personalized selection behaviour. Suboptimal brain dynamics is associated to
of drugs and stratification of patients for future clinical impaired adaptability, possibly leading to functional
trials. deficiencies. We hypothesize that impaired flexibility in
brain activity can lead to motor and cognitive symp-
Keywords: GABA, conductance-based modelling, dynamic toms of Parkinson's disease (PD). To test this hypothesis,
causal modelling, frontotemporal dementia, progressive we studied the 'functional repertoire'-the number
supranuclear palsy of distinct configurations of neural activity-using
source-reconstructed magnetoencephalography in
Brain: a journal of neurology (2021), Vol. 144, No. 7 PD patients and controls. We found stereotyped brain
(33710299) (10 citations) dynamics and reduced flexibility in PD. The intensity of
this reduction was proportional to symptoms severity,
which can be explained by beta-band hyper-synchro-
Flexible brain dynamics underpins complex nization. Moreover, the basal ganglia were prominently
behaviours as observed in Parkinson's disease involved in the abnormal patterns of brain activity. Our
(2021) findings support the hypotheses that: symptoms in
PD relate to impaired brain flexibility, this impairment
Sorrentino, Pierpaolo; Rucco, Rosaria; Baselice, Fabio; preferentially involves the basal ganglia, and beta-band
De Micco, Rosa; Tessitore, Alessandro; Hillebrand, Arjan; hypersynchronization is associated with reduced brain
Mandolesi, Laura; Breakspear, Michael; Gollo, Leonardo flexibility. These findings highlight the importance of
L; Sorrentino, Giuseppe extensive functional repertoires for correct behaviour.

Institute for Applied Science and Intelligent Systems, Na- Scientific reports (2021), Vol. 11, No. 1 (33602980) (18
tional Research Council, Via Campi Flegrei 34, Pozzuoli, citations)
Italy. pierpaolo.sorrentino@collaboratore.uniparthenope.
it; Department of Motor Sciences and Wellness, University of
Naples Parthenope, Via Ammiraglio Ferdinando Acton, 38, Cortical connectivity of the nucleus basalis of
80133, Naples, Italy; Department of Engineering, University Meynert in Parkinson's disease and Lewy body
of Naples Parthenope, Centro Direzionale, Isola C4, 80143, dementias (2021)
Naples, Italy; Department of Advanced Medical and Surgi-
cal Sciences, University of Campania "Luigi Vanvitelli", via Oswal, Ashwini; Gratwicke, James; Akram, Harith;
Luciano Armanni 5, 80138, Naples, Italy; Department of Jahanshahi, Marjan; Zaborszky, Laszlo; Brown, Peter;
Clinical Neurophysiology and MEG Center, Amsterdam UMC, Hariz, Marwan; Zrinzo, Ludvic; Foltynie, Tom; Litvak,
Vrije Universiteit Amsterdam, Amsterdam Neuroscience, The Vladimir
Netherlands, De Boelelaan 1117, 1081HV, Amsterdam, The

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