Page 236 - MEGIN Book Of Abstracts - 2023

are discussed as examples, but the detailed applica- supplementary motor area and STN within the high
tions will be the subject of other articles. (21-30 Hz) but not low (13-21 Hz) beta frequency range
correlated with 'hyperdirect pathway' fibre densities
Keywords: Accelerometer, Coherence, EEG, EMG, Gait, Ki- between these structures. Furthermore, supplemen-
nematics, MEG, Movement, Movement disorders, Posture, tary motor area activity drove STN activity selectively
Sleep, fMRI at high beta frequencies suggesting that high beta
frequencies propagate from the cortex to the basal
Clinical neurophysiology: official journal of the ganglia via the hyperdirect pathway. Computational
International Federation of Clinical Neurophysiology modelling revealed that exaggerated high beta hyper-
(2021), Vol. 132, No. 10 (34488012) (7 citations) direct pathway activity can provoke the generation
of widespread pathological synchrony at lower beta
frequencies. These findings suggest a spectral signa-
Neural signatures of hyperdirect pathway activity in ture and a pathophysiological role for the hyperdirect
Parkinson's disease (2021) pathway in PD.

Oswal, Ashwini; Cao, Chunyan; Yeh, Chien-Hung; Nature communications (2021), Vol. 12, No. 1 (34465771)
Neumann, Wolf-Julian; Gratwicke, James; Akram, Harith; (18 citations)
Horn, Andreas; Li, Dianyou; Zhan, Shikun; Zhang, Chao;
Wang, Qiang; Zrinzo, Ludvic; Foltynie, Tom; Limousin,
Patricia; Bogacz, Rafal; Sun, Bomin; Husain, Masud; Functional connectivity of spoken language
Brown, Peter; Litvak, Vladimir processing in early-stage Parkinson's disease: An
MEG study (2021)
The Wellcome Centre for Human Neuroimaging, University
College London, London, UK. [email protected]. Hyder, Rasha; Jensen, Mads; Højlund, Andreas; Kimppa,
uk; Department of Neurosurgery, Affiliated Ruijin Hospital, Lilli; Bailey, Christopher J; Schaldemose, Jeppe L;
School of Medicine, Shanghai JiaoTong University, Shanghai, Kinnerup, Martin B; Østergaard, Karen; Shtyrov, Yury
China; School of Information and Electronics Engineering,
Beijing Institute of Technology, Beijing, China; Department of Center of Functionally Integrative Neuroscience (CFIN),
Neurology, Charité University, Berlin, Germany; Department Department of Clinical Medicine, Aarhus University, Aarhus,
of Clinical and Movement Neurosciences, University College Denmark; Institute of Clinical Neuroscience and Medical
London, London, UK; Nuffield Department of Clinical Neu- Psychology, Heinrich-Heine University Düsseldorf, Düsseldorf,
rosciences, University of Oxford, Oxford, UK; Nuffield Depart- Germany. Electronic address: [email protected]; Center
ment of Clinical Neurosciences, University of Oxford, Oxford, of Functionally Integrative Neuroscience (CFIN), Department
UK. [email protected]; The Wellcome Centre for of Clinical Medicine, Aarhus University, Aarhus, Denmark;
Human Neuroimaging, University College London, London, Research Unit for Robophilosophy and Integrative Social
UK. [email protected] Robotics, Aarhus University, Denmark; Center of Functionally
Integrative Neuroscience (CFIN), Department of Clinical Medi-
ABSTRACT Parkinson's disease (PD) is characterised by cine, Aarhus University, Aarhus, Denmark; Cognitive Brain
the emergence of beta frequency oscillatory synchro- Research Unit, Department of Psychology and Logopedics,
nisation across the cortico-basal-ganglia circuit. The Faculty of Medicine, University of Helsinki, Finland; Depart-
relationship between the anatomy of this circuit and ment of Nuclear Medicine and PET Centre, Aarhus University
oscillatory synchronisation within it remains unclear. Hospital, Aarhus, Denmark; Sano Private Hospital, Denmark;
We address this by combining recordings from human Department of Neurology, Aarhus University Hospital (AUH),
subthalamic nucleus (STN) and internal globus pallidus Denmark; Center of Functionally Integrative Neuroscience
(GPi) with magnetoencephalography, tractography (CFIN), Department of Clinical Medicine, Aarhus University,
and computational modelling. Coherence between Aarhus, Denmark; Centre for Cognition and Decision Making,

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