Page 235 - MEGIN Book Of Abstracts - 2023

A novel approach to understanding Parkinsonian Evaluation of movement and brain activity (2021)
cognitive decline using minimum spanning trees,
edge cutting, and magnetoencephalography (2021) Hallett, Mark; DelRosso, Lourdes M; Elble, Rodger;
Ferri, Raffaele; Horak, Fay B; Lehericy, Stephan;
Simon, Olivier B; Buard, Isabelle; Rojas, Donald C; Mancini, Martina; Matsuhashi, Masao; Matsumoto, Riki;
Holden, Samantha K; Kluger, Benzi M; Ghosh, Debashis Muthuraman, Muthuraman; Raethjen, Jan; Shibasaki,
Hiroshi
Department of Biostatistics and Informatics, Colorado School
of Public Health, University of Colorado Anschutz Medical Human Motor Control Section, National Institute of Neu-
Campus, Aurora, CO, USA; Department of Neurology, Univer- rological Disorders and Stroke, NIH, Bethesda, MD, USA.
sity of Colorado School of Medicine, University of Colorado Electronic address: [email protected]; Department
Anschutz Medical Campus, Aurora, CO, USA; Department of of Pediatrics, University of Washington, Seattle, WA, USA;
Psychology, Colorado State University, Fort Collins, CO, USA; Department of Neurology, Southern Illinois University School
Department of Neurology, University of Rochester Medical of Medicine, Springfield, IL, USA; Oasi Research Institute -
Center, Rochester, NY, USA; Department of Biostatistics and IRCCS, Troina, Italy; Department of Neurology, Oregon Health
Informatics, Colorado School of Public Health, University & Science University, Portland, OR, USA; Paris Brain Institute
of Colorado Anschutz Medical Campus, Aurora, CO, USA. (ICM), Centre de NeuroImagerie de Recherche (CENIR), Team
[email protected] "Movement, Investigations and Therapeutics" (MOV'IT),
INSERM U 1127, CNRS UMR 7225, Sorbonne Université, Paris,
ABSTRACT Graph theory-based approaches are effi- France; Department of Epilepsy, Movement Disorders and
cient tools for detecting clustering and group-wise dif- Physiology, Kyoto University Graduate, School of Medicine,
ferences in high-dimensional data across a wide range Japan; Division of Neurology, Kobe University Graduate
of fields, such as gene expression analysis and neural School of Medicine, Japan; Section of Movement Disorders
connectivity. Here, we examine data from a cross-sec- and Neurostimulation, Biomedical Statistics and Multimodal
tional, resting-state magnetoencephalography study Signal Processing unit, Department of Neurology, Focus Pro-
of 89 Parkinson's disease patients, and use minimum- gram Translational Neuroscience (FTN), University Medical
spanning tree (MST) methods to relate severity of Par- Center of the Johannes Gutenberg-University Mainz, Mainz,
kinsonian cognitive impairment to neural connectivity Germany; Neurology Outpatient Clinic, Preusserstr. 1-9, 24105
changes. In particular, we implement the two-sample Kiel, Germany; Kyoto University Graduate School of Medicine,
multivariate-runs test of Friedman and Rafsky (Ann Stat Japan
7(4):697-717, 1979) and find it to be a powerful para-
digm for distinguishing highly significant deviations ABSTRACT Clinical neurophysiology studies can con-
from the null distribution in high-dimensional data. We tribute important information about the physiology
also generalize this test for use with greater than two of human movement and the pathophysiology and
classes, and show its ability to localize significance to diagnosis of different movement disorders. Some tech-
particular sub-classes. We observe multiple indications niques can be accomplished in a routine clinical neuro-
of altered connectivity in Parkinsonian dementia that physiology laboratory and others require some special
may be of future use in diagnosis and prediction. equipment. This review, initiating a series of articles
on this topic, focuses on the methods and techniques.
Scientific reports (2021), Vol. 11, No. 1 (34611218) (0 The methods reviewed include EMG, EEG, MEG, evoked
citations) potentials, coherence, accelerometry, posturography
(balance), gait, and sleep studies. Functional MRI (fMRI)
is also reviewed as a physiological method that can be
used independently or together with other methods. A
few applications to patients with movement disorders

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