Page 230 - MEGIN Book Of Abstracts - 2023

Keywords: Parkinson's disease, deep brain stimulation, differed from previous cues, β power in the STN and
magnetoencephalography, non-motor cerebral activity, cortex first decreased and then increased. Importantly,
somatosensory processing the conflict signal in the STN outlasted the cortical one,
carrying over to the next cue in the sequence. Further-
The European journal of neuroscience (2022), Vol. 56, No. more, after a conflict, there was an increase in coher-
2 (35560964) (1 citation) ence between the dorsal premotor cortex and STN in
the β band. These results extend our understanding
of cortico-subcortical dynamics of conflict processing,
Conflict Detection in a Sequential Decision Task and do so in a context where evidence must be ac-
Is Associated with Increased Cortico-Subthalamic cumulated in discrete steps, much like in real life. Thus,
Coherence and Prolonged Subthalamic Oscillatory the present work leads to a more nuanced picture of
Response in the β Band (2022) conflict monitoring systems in the brain and potential
changes because of disease.SIGNIFICANCE STATEMENT
Patai, E Zita; Foltynie, Thomas; Limousin, Patricia; Decision-making often involves the integration of mul-
Akram, Harith; Zrinzo, Ludvic; Bogacz, Rafal; Litvak, tiple pieces of information over time to make accurate
Vladimir predictions. We simultaneously recorded whole-head
magnetoencephalography (MEG) and local field poten-
Department of Psychology, School of Biological and Be- tials (LFPs) from the human subthalamic nucleus (STN)
havioral Sciences, Queen Mary University, London E1 4NS, in a novel task which required integrating sequen-
United Kingdom; Functional Neurosurgery Unit, The National tially presented pieces of evidence. Our key finding is
Hospital for Neurology and Neurosurgery and Department prolonged β oscillations in the STN, with a concurrent
of Clinical and Movement Neurosciences, University Col- increase in communication with frontal cortex, when
lege London Queen Square Institute of Neurology, London presented with conflicting information. These neural ef-
WC1N 3BG, United Kingdom; Medical Research Council Brain fects reflect the behavioral profile of reduced tendency
Network Dynamics Unit, Oxford University, Oxford OX1 3TH, to respond after conflict, as well as relate to subopti-
United Kingdom [email protected]; Wellcome mal cue integration in patients, which may be directly
Centre for Human Neuroimaging, University College London linked to clinically reported side-effects of deep-brain
Queen Square Institute of Neurology, London WC1N 3AR, stimulation (DBS) such as impaired decision-making
United Kingdom and impulsivity.

ABSTRACT Making accurate decisions often involves Keywords: DBS, coherence, conflict, dorsal premotor cor-
the integration of current and past evidence. Here, we tex, evidence integration, human, subthalamic nucleus
examine the neural correlates of conflict and evidence
integration during sequential decision-making. Female The Journal of neuroscience: the official journal of the
and male human patients implanted with deep-brain Society for Neuroscience (2022), Vol. 42, No. 23 (35501153)
stimulation (DBS) electrodes and age-matched and (1 citation)
gender-matched healthy controls performed an
expanded judgment task, in which they were free to
choose how many cues to sample. Behaviorally, we Cortical oscillatory dysfunction in Parkinson disease
found that while patients sampled numerically more during movement activation and inhibition (2022)
cues, they were less able to integrate evidence and
showed suboptimal performance. Using recordings Disbrow, Elizabeth A; Glassy, Nathaniel D; Dressler,
of magnetoencephalography (MEG) and local field Elizabeth M; Russo, Kimberley; Franz, Elizabeth A;
potentials (LFPs; in patients) in the subthalamic nucleus Turner, Robert S; Ventura, Maria I; Hinkley, Leighton;
(STN), we found that β oscillations signaled conflict Zweig, Richard; Nagarajan, Srikantan S; Ledbetter,
between cues within a sequence. Following cues that Christina R; Sigvardt, Karen A

 ontents  Index 209
C