Page 227 - MEGIN Book Of Abstracts - 2023

Functional connectivity maps of theta/alpha and and simultaneous magnetoencephalography. Using a
beta coherence within the subthalamic nucleus novel data set of 21 PD patients, we replicated previ-
region (2022) ously reported cortico-STN coherence networks in the
theta/alpha and beta frequency ranges, and looked for
van Wijk, Bernadette C M; Neumann, Wolf-Julian; the spatial distribution of these networks within the
Kroneberg, Daniel; Horn, Andreas; Irmen, Friederike; STN region. Although theta/alpha and beta coherence
Sander, Tilmann H; Wang, Qiang; Litvak, Vladimir; Kühn, peaks were both observed in on-medication record-
Andrea A ings from electrode contacts at several locations within
and around the STN, sites with theta/alpha coherence
Department of Human Movement Sciences, Faculty of peaks were situated at significantly more inferior MNI
Behavioural and Movement Sciences, Vrije Universiteit Am- coordinates than beta coherence peaks. Sites with only
sterdam, the Netherlands; Integrative Model-based Cognitive theta/alpha coherence peaks, i.e. without distinct beta
Neuroscience Research Unit, Department of Psychology, coherence, were mostly located near the border of
University of Amsterdam, the Netherlands; Movement Disor- sensorimotor and cognitive/associative subregions as
der and Neuromodulation Unit, Department of Neurology, defined by a tractography-based atlas of the STN. Peak
Charité - Universitätsmedizin Berlin, corporate member of coherence values were largely unaltered by the medi-
Freie Universität Berlin, Humboldt-Universität zu Berlin, and cation state of the subject, however, theta/alpha peaks
Berlin Institute of Health, Berlin, Germany; Wellcome Centre were more often identified in recordings obtained
for Human Neuroimaging, University College London, UK. after administration of dopaminergic medication. Our
Electronic address: [email protected]; Movement Disor- findings suggest the existence of a frequency-specific
der and Neuromodulation Unit, Department of Neurology, topography of cortico-STN coherence within the STN,
Charité - Universitätsmedizin Berlin, corporate member of albeit with considerable spatial overlap between func-
Freie Universität Berlin, Humboldt-Universität zu Berlin, and tional networks. Consequently, optimization of deep
Berlin Institute of Health, Berlin, Germany; Center for Brain brain stimulation targeting might remain a trade-off
Circuit Therapeutics, Department of Neurology, Brigham & between alleviating motor symptoms and avoiding
Women's Hospital, Harvard Medical School, Boston, USA; adverse neuropsychiatric side effects.
MGH Neurosurgery & Center for Neurotechnology and Neu-
rorecovery (CNTR), MGH Neurology, Massachusetts General Keywords: Deep brain stimulation, Functional connec-
Hospital, Harvard Medical School, Boston, USA; Physikalisch- tivity, Magnetoencephalography, Parkinson's disease,
Technische Bundesanstalt, Institut Berlin, Germany; Move- Subthalamic nucleus
ment Disorder and Neuromodulation Unit, Department of
Neurology, Charité - Universitätsmedizin Berlin, corporate NeuroImage (2022), Vol. 257 (35580809) (0 citations)
member of Freie Universität Berlin, Humboldt-Universität zu
Berlin, and Berlin Institute of Health, Berlin, Germany; Neuro-
Cure Clinical Research Centre, Charité - Universitätsmedizin Cortical beta burst dynamics are altered in
Berlin, Germany; DZNE, German Center for Degenerative Parkinson's disease but normalized by deep brain
Diseases, Berlin, Germany stimulation (2022)

ABSTRACT The subthalamic nucleus (STN) is a primary Pauls, K Amande M; Korsun, Olesia; Nenonen, Jukka;
target for deep brain stimulation in Parkinson's disease Nurminen, Jussi; Liljeström, Mia; Kujala, Jan; Pekkonen,
(PD). Although small in size, the STN is commonly par- Eero; Renvall, Hanna
titioned into sensorimotor, cognitive/associative, and
limbic subregions based on its structural connectivity Department of Neurology, Helsinki University Hospital and
profile to cortical areas. We investigated whether such Department of Clinical Neurosciences (Neurology), University
a regional specialization is also supported by functional of Helsinki, Helsinki, Finland; BioMag Laboratory, HUS Medi-
connectivity between local field potential recordings cal Imaging Center, University of Helsinki, Aalto University,

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