Page 246 - MEGIN Book Of Abstracts - 2023

contralateral akinesia scores. Our findings suggest that for deep brain stimulation (DBS) to look for differences
particular frequency bands and brain regions display in underlying resting-state network pathophysiology.
nonlinear features closely associated with distinct mo- In both patient groups we observed spectral peaks in
tor symptoms and functions. the theta (2-8 Hz) band in both the NBM and the GPi.
Furthermore, both the NBM and the GPi exhibited simi-
Keywords: Deep brain stimulation, Dopamine, Levodopa, lar spatial and spectral patterns of coupling with the
Local field potentials, Neural oscillations, Nonlinearity cortex in the two disease states. Specifically, we report
two distinct coherent networks between the NBM/GPi
NeuroImage (2020), Vol. 223 (32916287) (4 citations) and cortical regions: (1) a theta band (2-8 Hz) network
linking the NBM/GPi to temporal cortical regions, and
(2) a beta band (13-22 Hz) network coupling the NBM/
Resting state activity and connectivity of the GPi to sensorimotor areas. We also found differences
nucleus basalis of Meynert and globus pallidus between the two disease groups: oscillatory power in
in Lewy body dementia and Parkinson's disease the low beta (13-22Hz) band was significantly higher
dementia (2020) in the globus pallidus in PDD patients compared to
DLB, and coherence in the high beta (22-35Hz) band
Gratwicke, James; Oswal, Ashwini; Akram, Harith; between the globus pallidus and lateral sensorimotor
Jahanshahi, Marjan; Hariz, Marwan; Zrinzo, Ludvic; cortex was significantly higher in DLB patients com-
Foltynie, Tom; Litvak, Vladimir pared to PDD. Overall, our findings reveal coherent
networks of the NBM/GPi region that are common to
Department of Clinical and Movement Neurosciences, UCL both DLB and PDD. Although the neurophysiological
Institute of Neurology and The National Hospital for Neurol- differences between the two conditions in this study
ogy and Neurosurgery, Queen Square, London, UK; Nuffield are confounded by systematic differences in DBS lead
Department of Clinical Neurosciences, John Radcliffe Hospi- trajectories and motor symptom severity, they lend
tal, Oxford, UK; Wellcome Centre for Human Neuroimaging, support to the hypothesis that DLB and PDD, though
UCL Institute of Neurology, 12 Queen Square, London, UK; closely related, are distinguishable from a neurophysi-
Department of Clinical and Movement Neurosciences, UCL ological perspective.
Institute of Neurology and The National Hospital for Neurol-
ogy and Neurosurgery, Queen Square, London, UK; Wellcome Keywords: Basal forebrain, Basal ganglia, Human, Network,
Centre for Human Neuroimaging, UCL Institute of Neurology, Pallidum
12 Queen Square, London, UK; Wellcome Centre for Human
Neuroimaging, UCL Institute of Neurology, 12 Queen Square, NeuroImage (2020), Vol. 221 (32711059) (10 citations)
London, UK. Electronic address: [email protected]

ABSTRACT Parkinson's disease dementia (PDD) and L-dopa treatment increases oscillatory power in the
dementia with Lewy bodies (DLB) are two related motor cortex of Parkinson's disease patients (2020)
diseases which can be difficult to distinguish. There is
no objective biomarker which can reliably differenti- Cao, Chunyan; Li, Dianyou; Zhan, Shikun; Zhang,
ate between them. The synergistic combination of Chencheng; Sun, Bomin; Litvak, Vladimir
electrophysiological and neuroimaging approaches
is a powerful method for interrogation of functional Department of Neurosurgery, Affiliated Ruijin Hospital,
brain networks in vivo. We recorded bilateral local field Shanghai JiaoTong University School of Medicine, Shanghai,
potentials (LFPs) from the nucleus basalis of Meynert 200025, China; Wellcome Centre for Human Neuroimaging,
(NBM) and the internal globus pallidus (GPi) with UCL Queen Square Institute of Neurology, London WC1N
simultaneous cortical magnetoencephalography (MEG) 3BG, UK; Department of Neurosurgery, Affiliated Ruijin
in six PDD and five DLB patients undergoing surgery Hospital, Shanghai JiaoTong University School of Medicine,

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