Page 254 - MEGIN Book Of Abstracts - 2023

for Neurosciences, Vrije Universiteit Brussel (VUB), Universitair Keywords: Magnetoencephalography, Multiple sclerosis,
Ziekenhuis Brussel (UZ Brussel), Laarbeeklaan 101, 1090 Brus- Resting state, Spectral power, Structural neuroimaging
sels, Belgium; National MS Center Melsbroek, 1820 Melsbroek,
Belgium; Computational Neuroscience Group, Universitat NeuroImage. Clinical (2021), Vol. 30 (33770549) (3
Pompeu Fabra, Spain; Laboratoire de Cartographie fonction- citations)
nelle du Cerveau, UNI-ULB Neuroscience Institute, Université
libre de Bruxelles (ULB), Brussels, Belgium; Magnetoencepha-
lography Unit, Department of Functional Neuroimaging, Functional brain network organization measured
Service of Nuclear Medicine, CUB-Hôpital Erasme, Brussels, with magnetoencephalography predicts cognitive
Belgium; Neurology, Center for Neurosciences, Vrije Universit- decline in multiple sclerosis (2021)
eit Brussel (VUB), Universitair Ziekenhuis Brussel (UZ Brussel),
Laarbeeklaan 101, 1090 Brussels, Belgium; AIMS, Center for Nauta, Ilse M; Kulik, Shanna D; Breedt, Lucas C; Eijlers,
Neurosciences, Vrije Universiteit Brussel (VUB), Laarbeeklaan Anand Jc; Strijbis, Eva Mm; Bertens, Dirk; Tewarie,
103, 1090 Brussels, Belgium; National MS Center Melsbroek, Prejaas; Hillebrand, Arjan; Stam, Cornelis J; Uitdehaag,
1820 Melsbroek, Belgium; St Edmund Hall, University of Bernard Mj; Geurts, Jeroen Jg; Douw, Linda; de Jong,
Oxford, United Kingdom Brigit A; Schoonheim, Menno M

ABSTRACT In multiple sclerosis, the interplay of Department of Neurology, Amsterdam UMC, Vrije Universiteit
neurodegeneration, demyelination and inflammation Amsterdam, MS Center Amsterdam, Amsterdam Neurosci-
leads to changes in neurophysiological functioning. ence, Amsterdam, The Netherlands; Department of Anatomy
This study aims to characterize the relation between & Neurosciences, Amsterdam UMC, Vrije Universiteit Am-
reduced brain volumes and spectral power in multiple sterdam, MS Center Amsterdam, Amsterdam Neuroscience,
sclerosis patients and matched healthy subjects. During Amsterdam, The Netherlands; Department of Neurology,
resting-state eyes closed, we collected magnetoen- Amsterdam UMC, Vrije Universiteit Amsterdam, MS Center
cephalographic data in 67 multiple sclerosis patients Amsterdam, Amsterdam Neuroscience, Amsterdam, The
and 47 healthy subjects, matched for age and gender. Netherlands/Department of Clinical Neurophysiology and
Additionally, we quantified different brain volumes MEG Center, Amsterdam UMC, Vrije Universiteit Amsterdam,
through magnetic resonance imaging (MRI). First, a MS Center Amsterdam, Amsterdam Neuroscience, Amster-
principal component analysis of MRI-derived brain dam, The Netherlands; Donders Institute for Brain, Cognition
volumes demonstrates that atrophy can be largely de- and Behaviour, Radboud University, Nijmegen, The Neth-
scribed by two components: one overall degenerative erlands; Klimmendaal Rehabilitation Center, Arnhem, The
component that correlates strongly with different cog- Netherlands
nitive tests, and one component that mainly captures
degeneration of the cortical grey matter that strongly BACKGROUND Cognitive decline remains difficult to
correlates with age. A multimodal correlation analysis predict as structural brain damage cannot fully ex-
indicates that increased brain atrophy and lesion load is plain the extensive heterogeneity found between MS
accompanied by increased spectral power in the lower patients.
alpha (8-10 Hz) in the temporoparietal junction (TPJ).
Increased lower alpha power in the TPJ was further OBJECTIVE To investigate whether functional brain
associated with worse results on verbal and spatial network organization measured with magnetoen-
working memory tests, whereas an increased lower/ cephalography (MEG) predicts cognitive decline in MS
upper alpha power ratio was associated with slower patients after 5 years and to explore its value beyond
information processing speed. In conclusion, multiple structural pathology.
sclerosis patients with increased brain atrophy, lesion
and thalamic volumes demonstrated increased lower METHODS Resting-state MEG recordings, structural
alpha power in the TPJ and reduced cognitive abilities. MRI, and neuropsychological assessments were ana-

 ontents  Index 233
C