Page 253 - MEGIN Book Of Abstracts - 2023

Keywords: Biomarkers, Brain network function, Eye move- an association between upper alpha connectivity and
ment, Magnetoencephalography, Multiple sclerosis, cognitive measures in people with MS. Overall studies
Neuro-ophthalmology were of moderate quality (mean mJBI score 6.7).

NeuroImage. Clinical (2021), Vol. 32 (34624635) (2 DISCUSSION We find evidence for the utility of MEG in
citations) Multiple Sclerosis. Event-related designs are of particu-
lar value and show replicability between centres. At this
stage, it is not clear whether these changes are specific
The utility of Magnetoencephalography in multiple to Multiple Sclerosis or are also observable in other
sclerosis - A systematic review (2021) diseases. Further studies should look to explore cogni-
tive control in more depth using in-task designs and
Khan, H; Sami, M B; Litvak, V undertake longitudinal studies to determine whether
these changes have prognostic value.
UCL Queen's Square Institute of Neurology, Queen Square,
London WC1N 3BG, United Kingdom; Queen's Medical Centre Keywords: Biomarker, Cognition, Connectivity, Magneto-
Nottingham, Clifton Boulevard, Derby Rd, Nottingham NG7 encephalography, Multiple sclerosis, Neuroinflammation
2UH, United Kingdom. Electronic address: hinakhan1@nhs.
net; Institute of Mental Health, Jubilee Campus, University of NeuroImage. Clinical (2021), Vol. 32 (34537682) (1 citation)
Nottingham Innovation Park, Triumph Road, Nottingham
NG7 2TU, United Kingdom
Increased brain atrophy and lesion load is
INTRODUCTION Magnetoencephalography (MEG), al- associated with stronger lower alpha MEG power in
lows for a high degree temporal and spatial accuracy in multiple sclerosis patients (2021)
recording cortical oscillatory activity and evoked fields.
To date, no review has been undertaken to synthesise Van Schependom, Jeroen; Vidaurre, Diego; Costers,
all MEG studies in Multiple Sclerosis (MS). We under- Lars; Sjøgård, Martin; Sima, Diana M; Smeets, Dirk;
took a Systematic Review of the utility of MEG in MS. D'hooghe, Marie Beatrice; D'haeseleer, Miguel; Deco,
Gustavo; Wens, Vincent; De Tiège, Xavier; Goldman,
METHODS We identified MEG studies carried out in MS Serge; Woolrich, Mark; Nagels, Guy
using EMBASE, Medline, Cochrane, TRIP and Psychinfo
databases. We included original research articles with Neurology, Center for Neurosciences, Vrije Universiteit Brussel
a cohort of minimum of five multiple sclerosis patients (VUB), Universitair Ziekenhuis Brussel (UZ Brussel), Laarbeek-
and quantifying of at least one MEG parameter. We laan 101, 1090 Brussels, Belgium; AIMS, Center for Neurosci-
used a modified version of the JBI (mJBI) for case-con- ences, Vrije Universiteit Brussel (VUB), Laarbeeklaan 103, 1090
trol studies to assess for risk of bias. Brussels, Belgium; Department of Electronics and Informat-
ics (ETRO), Vrije Universiteit Brussel, Pleinlaan 2, Brussels.
RESULTS We identified 30 studies from 13 centres Belgium. Electronic address: Jeroen.van.schependom@vub.
involving at least 433 MS patients and 347 controls. be; Oxford Centre for Human Brain Activity (OHBA), University
We found evidence that MEG shows perturbed activity of Oxford, United Kingdom; Oxford University Centre for Func-
(most commonly reduced power modulations), re- tional MRI of the Brain (FMRIB), University of Oxford, United
duced connectivity and association with altered clinical Kingdom; Center for Functionally Integrative Neuroscience,
function in Multiple Sclerosis. Specific replicated find- Department of Clinical Medicine, Aarhus University, Aarhus
ings were decreased motor induced responses in the 8000, Denmark; Laboratoire de Cartographie fonctionnelle
beta band, diminished increase of gamma power after du Cerveau, UNI-ULB Neuroscience Institute, Université libre
visual stimulation, increased latency and reduced con- de Bruxelles (ULB), Brussels, Belgium; icometrix NV, Kolonel
nectivity for somatosensory evoked fields. There was Begaultlaan 1b / 12, 3012 Leuven, Belgium; Neurology, Center

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