Page 142 - MEGIN Book Of Abstracts - 2023

Keywords: Drug-resistant epilepsy, Eigenvector centrality, were pathologically hypersynchronous and instanta-
Functional connectivity, Magnetoencephalography, Surgi- neous VNS can decrease the synchronization of brain
cal outcome networks of epileptic patients, which might play a key
role in the mechanism by which VNS reduces epileptic
Clinical neurophysiology: official journal of the seizures. In the theta band, instantaneous VNS can
International Federation of Clinical Neurophysiology increase the network efficiency of DRE patients, and the
(2022), Vol. 142 (36063669) (1 citation) increment in network efficiency may be helpful for im-
proving brain cognitive function in epileptic patients.
Impact statement For the first time, we investigated the
Immediate Effects of Vagal Nerve Stimulation immediate effects of vagus nerve stimulation (VNS) in
in Drug-Resistant Epilepsy Revealed by the brain networks of drug-resistant epilepsy patients
Magnetoencephalographic Recordings (2023) using magnetoencephalography. Our results show that
instantaneous VNS can decrease the hypersynchroniza-
Li, Yuejun; Zhu, Haitao; Chen, Qiqi; Yang, Lu; Chen, tion of epileptic networks and increase the network
Fangqing; Ma, Haiyan; Xu, Honghao; Chen, Kefan; Bu, efficiency of epileptic patients. Our results are helpful in
Jinxin; Zhang, Rui understanding the mechanism of action by which VNS
reduces epileptic seizures and improves the cognitive
Department of Magnetoencephalography, Affiliated Nanjing function in epileptic patients and the brain network
Brain Hospital, Nanjing Medical University, Nanjing, China; reorganization caused by long-term VNS.
Department of Functional Neurosurgery and Affiliated
Nanjing Brain Hospital, Nanjing Medical University, Nanjing, Keywords: brain networks, drug-resistant epilepsy, func-
China tional connectivity, graph theory, magnetoencephalogra-
phy, vagal nerve stimulation
ABSTRACT Objective: Vagus nerve stimulation (VNS)
has been a neuromodulatory option for treating drug- Brain connectivity (2023), Vol. 13, No. 1 (35974665) (0
resistant epilepsy (DRE), but its mechanism remains citations)
unclear. To obtain insight into the mechanism by which
VNS reduces epileptic seizures, the immediate effects
of VNS in brain networks of DRE patients were investi- Child Neurology: Functional Evaluation
gated when the patients' vagal nerve stimulators were of the Dominant Hemisphere Using
turned on. Methods: The brain network properties of Magnetoencephalography Prior to
14 DRE patients with a vagal nerve stimulator and 14 Hemispherectomy (2022)
healthy controls were evaluated using magnetoen-
cephalography recordings for 6 main frequency bands. Pavuluri, Spriha; Gumenyuk, Valentina; Koh, Sookyong;
Results: Compared with healthy controls, DRE patients Salehi, Afshin; Cathcart, Sahara; Taraschenko, Olga
exhibited significant increases in functional connectiv-
ity in the theta, alpha, beta, and gamma bands and From the Department of Neurological Sciences (S.P., V.G., S.K.,
significant reductions in the small-world measure in the S.C., O.T.), University of Nebraska Medical Center, Omaha, NE;
theta and beta bands. During periods when patients' and Department of Neurological Surgery (A.S.), University of
vagal nerve stimulators were turned on, DRE patients Nebraska Medical Center, Omaha Children's & Medical Cen-
showed significant reductions in functional connec- ter, NE; From the Department of Neurological Sciences (S.P.,
tivity in the theta and alpha bands and a significant V.G., S.K., S.C., O.T.), University of Nebraska Medical Center,
increase in the small-world measure in the theta band Omaha, NE; and Department of Neurological Surgery (A.S.),
when compared with periods when patients' vagal University of Nebraska Medical Center, Omaha Children's &
nerve stimulators were turned off. Conclusions: Our Medical Center, NE. [email protected]
results indicate that the brain networks of DRE patients

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