Page 137 - MEGIN Book Of Abstracts - 2023

CONCLUSIONS SeLECTS patients with cognitive im- MEG recordings during eating. Network changes were
pairment in the early stage of the disease developed analyzed using phase lag index across 5 frequency
disordered networks in cognitive-related brain regions. bands [delta, theta, alpha, beta, and gamma] using
The clustering coefficient in the 12-30 and 80-250 Hz clustering coefficient (CC), betweenness centrality (BC),
frequency bands as well as the path length in the path length (PL), modularity (Q), and small worldness
80-250 Hz frequency band might be good indicators (SW).
to distinguish the cognitive impairment of SeLECTS
patients at the early stage. RESULTS During the resting state, PL was decreased in
patients with epilepsy in the delta, theta, and gamma
Keywords: cognitive function, functional connectivity, band. Q was lower in patients with epilepsy in the beta
magnetoencephalography, multifrequency bands, self- and gamma bands. During eating, in patients with epi-
limited epilepsy with centrotemporal spikes lepsy, PL and SW were increased in all frequency bands,
and Q was decreased in the beta band and increased
Brain and behavior (2022), Vol. 12, No. 12 (36408856) (1 in the rest of the frequency bands. Patients with mixed
citation) types of seizures showed higher PL in all bands except
alpha, higher Q in all bands, and higher SW in the alpha
and beta bands. Node-wise changes in CC and BC im-
Network alterations in eating epilepsy plicated changes in DMN and 'eating' networks.
during resting state and during eating using
Magnetoencephalography (2022) CONCLUSION Reflex Eating epilepsy presents with
a hyperconnected network that exacerbates during
Gautham, Bhargava; Chatterjee, Aparajita; Kenchaiah, eating. The cause of seizure onset and loss of con-
Raghavendra; Narayanan, Mariyappa; Duble, Shishir; sciousness in eating epilepsy might be due to aberrant
Chowdary Mundlamuri, Ravindranadh; Asranna, Ajay; network interaction between the regions of the brain
Bharath, Rose Dawn; Saini, Jitender; Sinha, Sanjib involved with eating, such as the sensorimotor cortex,
lateral parietal cortex, and insula with the limbic cortex
MEG Research Lab, NIMHANS, Hosur Road, Bangalore, India; and default mode network across multiple frequency
Department of Neurology, NIMHANS, Hosur Road, Banga- bands.
lore, India; Department of Neuroimaging and Interventional
Radiology, NIMHANS, Hosur Road, Bangalore, India; MEG Keywords: Eating epilepsy, Graph theory, MEG, PLI
Research Lab, NIMHANS, Hosur Road, Bangalore, India;
Department of Neurology, NIMHANS, Hosur Road, Bangalore, Epilepsy & behavior: E&B (2022), Vol. 137, No. Pt A
India. Electronic address: [email protected] (36379187) (0 citations)

OBJECTIVE Eating epilepsy presents various imaging
and electrophysiological features along with various Data-driven approach for the delineation of the
seizure triggers. As such, network changes in eating irritative zone in epilepsy in MEG (2022)
epilepsy have not been comprehensively explored. This
study was conducted to illustrate resting state network Chirkov, Valerii; Kryuchkova, Anna; Koptelova,
changes in eating epilepsy and to study the changes in Alexandra; Stroganova, Tatiana; Kuznetsova, Alexandra;
network configurations during eating. Kleeva, Daria; Ossadtchi, Alexei; Fedele, Tommaso

METHODS Magnetoencephalography recordings of Berlin School of Mind and Brain, Humboldt University, Berlin,
nineteen patients with drug-resistant eating epilepsy Germany; Center for Neurocognitive Research, MEG Center,
were compared with healthy controls during resting MSUPE, Moscow, Russian Federation; Institute of Cognitive
state. A subgroup of nine patients and 12 controls had Neuroscience, National Research University Higher School of

 ontents  Index 116
C