Page 136 - MEGIN Book Of Abstracts - 2023

Concordance between ictal and interictal SECD Changes in functional connectivity in
localizations was significantly associated with seizure- newly diagnosed self-limited epilepsy with
freedom. Concordance between MRI lesion and ictal centrotemporal spikes and cognitive impairment:
SECD, concordance between ictal ICEEG and ictal and An MEG study (2022)
interictal SECD, as well as concordance between ictal
ICEEG and MRI lesion were significantly associated with Li, Yihan; Chen, Jinan; Sun, Jintao; Jiang, Ping; Xiang,
seizure freedom. Jing; Chen, Qiqi; Hu, Zheng; Wang, Xiaoshan

CONCLUSIONS Ictal MEG can contribute useful infor- Department of Neurology, The Affiliated Brain Hospital of
mation for delineating the resection area in epilepsy Nanjing Medical University, Nanjing, Jiangsu, China; MEG
surgery. Center, Division of Neurology, Cincinnati Children's Hospital
Medical Center, Cincinnati, Ohio, USA; MEG Center, Nanjing
SIGNIFICANCE Resection should include ictal, inter- Brain Hospital, Nanjing, Jiangsu, China; Department of Neu-
ictal SECDs and MRI lesion localization, when feasible. rology, Nanjing Children's Hospital, Nanjing, Jiangsu, China
Concordant ictal and interictal SECDs on MEG can be a
favorable predictor of seizure freedom. PURPOSE Our purpose was to explore the relationship
between cognitive impairment and neural network
Keywords: Epilepsy surgery, Epileptogenic zone, Ictal changes in patients newly diagnosed with self-limited
magnetoencephalography, Intracranial electroencepha- epilepsy with centrotemporal spikes (SeLECTS).
lography, Seizure free, Seizure outcome, Stereo-electroen-
cephalography METHODS The Wechsler Intelligence Scale for Children,
fourth edition was used to divide all SeLECTS patients
Clinical neurophysiology: official journal of the into two groups: patients with full-scale intelligence
International Federation of Clinical Neurophysiology quotient (FSIQ) below 80 that corresponded to cogni-
(2023), Vol. 145 (36443170) (1 citation) tive impairment, and patients with FSIQ above 80 that
corresponded to a normal cognitive function. The data
on the resting state were recorded using magnetoen-
Epilepsy highlight: Ictal MEG in epilepsy surgery cephalography. The properties of the networks were
candidates - Results from largest cohort (2023) analyzed using graph theory (GT) analysis.

Laohathai, Christopher; Funke, Michael RESULTS The functional connectivity (FC) of the frontal
cortex in patients with FSIQ < 80 was reduced in the
Department of Neurology, Saint Louis University, St. Louis, 12-30 Hz frequency band, and the FC of the posterior
MO, USA; Department of Pediatrics, University of Texas Health cingulate cortex was reduced in the 80-250 and 250-
Science Center, McGovern Medical School, Houston, TX, USA 500 Hz frequency bands. The GT analysis showed that
patients in the FSIQ < 80 group had higher strength in
Clinical neurophysiology: official journal of the the 8-12 and 12-30 Hz frequency bands than those in
International Federation of Clinical Neurophysiology the healthy control and FSIQ > 80 group. However, the
(2023), Vol. 145 (36435692) (0 citations) path length was reduced in the 80-250 Hz band, and
the clustering coefficient was reduced in the 12-30, 80-
250, and 250-500 Hz frequency bands. Moreover, the
receiver operator characteristic analysis showed that
the clustering coefficient in the 12-30 and 80-250 Hz
frequency bands, as well as the path length in the 80-
250 Hz frequency band possessed a good discrimina-
tive ability in distinguishing the FSIQ > 80 group.

 ontents  Index 115
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