Page 140 - MEGIN Book Of Abstracts - 2023

EMHapp: a pipeline for the automatic detection, margins or SOZs in comparison with conventional VS
localization and visualization of epileptic reconstruction approaches.Significance.EMHapp is the
magnetoencephalographic high-frequency first GUI-based pipeline for the analysis of epileptic
oscillations (2022) magnetoencephalographic HFOs, which conveniently
obtains HFO source locations using clinical data and
Cui, Wei; Cao, Miao; Wang, Xiongfei; Zheng, Li; Cen, enables direct translation to clinical applications.
Zhehang; Teng, Pengfei; Luan, Guoming; Gao, Jia-Hong
Keywords: MEG, beamformer, epilepsy, high-frequency
Center for MRI Research, Academy for Advanced Interdisci- oscillations, interictal epileptic discharges
plinary Studies, Peking University, Beijing, People's Republic of
China; Department of Neurosurgery, Beijing Key Laboratory Journal of neural engineering (2022), Vol. 19, No. 5
of Epilepsy, Sanbo Brain Hospital Capital Medical University, (36108595) (0 citations)
Beijing, People's Republic of China; Institute of Artificial Intel-
ligence, Hefei Comprehensive National Science Center, Hefei,
Anhui, People's Republic of China The long-term surgical outcomes of low-grade
epilepsy-associated neuroepithelial tumors (2022)
ABSTRACT Objective.High-frequency oscillations
(HFOs) are promising biomarkers for localizing epilep- Xie, Ming-Guo; Wang, Xiong-Fei; Qiao, Jiao; Zhou, Jian;
togenic brain tissue. Previous studies have revealed Guan, Yu-Guang; Liu, Chang-Qing; Zhao, Meng; Li, Tian-
that HFOs that present concurrence with interictal epi- Fu; Luan, Guo-Ming
leptic discharges (IEDs) better delineate epileptogenic
brain tissue, particularly for epilepsy patients with Beijing Key Laboratory of Epilepsy, Sanbo Brain Hospital,
multitype interictal discharges. However, the analysis Capital Medical University, Beijing, China; Department of
of noninvasively recorded epileptic HFOs involves Neurology, Epilepsy Center, Sanbo Brain Hospital, Capital
many complex procedures, such as data preprocessing, Medical University, Beijing, China; Beijing Institute for Brain
detection and source localization, impeding the trans- Disorders, Capital Medical University, Beijing, China
lation of this approach to clinical practice.Approach.
To address these problems, we developed a graphical OBJECTIVE This study aimed to evaluate the surgical
user interface (GUI)-based pipeline called EMHapp, outcomes and relevant prognostic factors in patients
which can be used for the automatic detection, source with low-grade epilepsy-associated neuroepithelial
localization and visualization of HFO events concur- tumors (LEAT) and, especially, to develop a scoring
ring with IEDs in magnetoencephalography (MEG) system to predict postoperative seizure outcomes.
signals by using a beamformer-based virtual sensor
(VS) technique. An improved VS reconstruction method METHODS The clinical data of patients who underwent
was developed to enhance the amplitudes of both HFO epilepsy surgery for LEAT were retrospectively studied.
and IED VS signals. To test the capability of our pipeline, The surgical outcomes of seizure and neurological
we collected MEG data from 11 complex focal epilepsy statuses in patients were evaluated using Engel clas-
patients with surgical resections or seizure onset zones sification and modified Rankin Scale (mRS) scoring,
(SOZs) that were identified by intracranial electroen- respectively. A scoring system of seizure outcomes was
cephalography.Main results.Our results showed that constructed based on the weight of the β-coefficient
the HFO sources of eight patients were concordant estimate of each predictor in the final multivariate
with their resection margins or SOZs. Our proposed predicting model of seizure outcomes.
VS signal reconstruction approach achieved an 83.2%
improvement regarding the number of detected HFO RESULTS Of the 287 patients (106 female) enrolled,
events and a 17.3% improvement in terms of the spatial the median age was 19 years at surgery and 10 years
overlaps between the HFO sources and the resection at seizure onset, with a median duration of epilepsy of

 ontents  Index 119
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