Page 143 - MEGIN Book Of Abstracts - 2023

ABSTRACT Rasmussen encephalitis is a devastating variables were analyzed and corelated to the postop-
progressive inflammatory disorder that leads to debili- erative seizure freedom.
tating neurologic deficits and intractable epilepsy. Sur-
gical treatment of the dominant hemisphere has been RESULTS Fourteen patients were identified, 6 under-
attempted with hesitation, given the lack of effective went PQD and 8 underwent CC. At follow up of 39.17
diagnostic tools to determine the potential functional ± 23.75 months, 66.66% of patients (4/6) in the PQD
deficits from disconnection procedures. subgroup had an ILAE Class I outcome. While none in
the CC group attained seizure freedom, 87.5% (7/8)
Neurology (2022), Vol. 99, No. 14 (35918155) (0 citations) had more than 50% reduction in seizure frequency
(follow up: 42 ± 27.31 months). Patients with a poor
outcome had significantly greater seizure frequency (P
Feasibility of Tailored Unilateral Disconnection vs = 0.05) and history of drop attacks (P = 0.04) in both the
Callosotomy for Refractory Epilepsy in Patients groups. Magnetoencephalography (MEG) accurately
with Bilateral Parieto-Occipital Gliosis Following localized the epileptogenic zone in all of the patients
Perinatal Insult (2022) with good outcome (P = 0.015). Concordance with
single photon emission tomography (SPECT) was also a
Agrawal, Mohit; Chandra, Sarat P; Doddamani, Ramesh predictor of favorable outcome (P = 0.041).
S; Samala, Raghu; Garg, Ajay; Gaikwad, Shailesh;
Sharma, Ravi; Ramanujan, Bhargavi; Tripathi, Madhavi; CONCLUSIONS A history of drop attacks with high
Bal, Chandrashekar; Tripathi, Manjari seizure frequency is associated with poor postoperative
seizure outcome. Unilateral PQD is feasible and leads
Department of Neurosurgery, All India Institute of Medical to superior seizure-free outcomes, even in cases with
Sciences, New Delhi, India; Department of Neuroradiology, All widespread and bilateral imaging and electrical abnor-
India Institute of Medical Sciences, New Delhi, India; Depart- malities, provided the other preoperative investigations
ment of Neurology, All India Institute of Medical Sciences, are concordant in localizing the epileptogenic zone.
New Delhi, India; Department of Nuclear Medicine, All India
Institute of Medical Sciences, New Delhi, India Keywords: Drug refractory epilepsy, hypoxic ischemic
encephalopathy, pediatric epilepsy, perinatal hypoxia,
BACKGROUND Patients with perinatal hypoxia (PH) posterior quadrant disconnection
and drug-refractory epilepsy (DRE) often have bilateral
parieto-occipital gliosis. Surgical management of such Neurology India (2022), Vol. 70, No. 3 (35864619) (0
patients is a dilemma. citations)

OBJECTIVE To identify preoperative determinants for
unilateral disconnection vs callosotomy, and analyze Characterization of cortical activity in juvenile
the surgical outcome in such patients. myoclonic epilepsy by gradient magnetic field
topography (2022)
METHODS AND MATERIAL This was a retrospective
analysis of patients with DRE and history of PH, with Kagawa, Kota; Iida, Koji; Hashizume, Akira; Katagiri,
MRI abnormalities restricted to bilateral posterior Masaya; Seyama, Go; Okamura, Akitake; Horie,
quadrants. Preoperative semiology, epilepsy duration Nobutaka
and seizure frequency were recorded. Based on the
concordance between the results of non-invasive tests, Department of Neurosurgery, Hiroshima University Hospital,
patients underwent either posterior quadrant discon- 1-2-3 Kasumi, Minami-ku, Hiroshima City 734-0037, Japan;
nection (PQD) or corpus callosotomy (CC). Preoperative Epilepsy Center, Hiroshima University Hospital, 1-2-3 Kasumi,
Minami-ku, Hiroshima City 734-0037, Japan; Epilepsy Center,

 ontents  Index 122
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