Page 148 - MEGIN Book Of Abstracts - 2023

of 0.7) times higher (P < .001) with on-scalp MEG, and of MEG and some potential clinical applications are
the SNR was 27% (16.7 of 13.2) to 60% (12.8 of 8.0) briefly reviewed.
higher (P value range: .001-.009) with on-scalp MEG
in all but one participant (P = .93), whose head move- Arquivos de neuro-psiquiatria (2022), Vol. 80, No. 5
ments created pronounced motion artifacts. The neural (35486819) (0 citations)
source of averaged IEDs was located at approximately
5 mm (n = 3) or higher (8.3 mm, n = 1; 15.6 mm, n =
1) between on-scalp and cryogenic MEG. Conclusion Fast parametric curve matching (FPCM) for
Despite the limited number of sensors and scalp cover- automatic spike detection (2022)
age, on-scalp magnetoencephalography (MEG) based
on optically pumped magnetometers helped detect in- Kleeva, Daria; Soghoyan, Gurgen; Komoltsev, Ilia;
terictal epileptiform discharges in school-aged children Sinkin, Mikhail; Ossadtchi, Alexei
with epilepsy with a higher amplitude, higher signal-
to-noise ratio, and similar localization value compared Center for Bioelectric Interfaces, Higher School of Economics,
with conventional cryogenic MEG. Online supplemen- Moscow, Russia; Moscow Research and Clinical Center for
tal material is available for this article. © RSNA, 2022 See Neuropsychiatry of the Healthcare Department of Moscow,
also the editorial by Widjaja in this issue. Moscow, Russia; NV Sklifosovsky Research Institute of Emer-
gency Medicine, Moscow, Russia; AIRI, Artificial Intelligence
Radiology (2022), Vol. 304, No. 2 (35503013) (7 citations) Research Institute, Moscow, Russia

ABSTRACT Objective. Epilepsy is a widely spread
Magnetoencephalography in clinical practice (2022) neurological disease, whose treatment often requires
resection of the pathological cortical tissue. Interictal
Hegazy, Mohamed; Gavvala, Jay spike analysis observed in the non-invasively collected
EEG or MEG data offers an attractive way to localize
Baylor College of Medicine, Neurology, Houston, Texas, United epileptogenic cortical structures for surgery plan-
States ning purposes. Interictal spike detection in lengthy
multichannel data is a daunting task that is still often
ABSTRACT Magnetoencephalography (MEG) is a performed manually. This frequently limits such an
neurophysiological technique that measures the analysis to a small portion of the data which renders
magnetic fields associated with neuronal activity in the the appropriate risks of missing the potentially epilep-
brain. It is closely related but distinct from its counter- togenic region. While a plethora of automatic spike
part electroencephalography (EEG). The first MEG was detection techniques have been developed each with
recorded more than 50 years ago and has technologi- its own assumptions and limitations, none of them is
cally evolved over this time. It is now well established ideal and the best results are achieved when the output
in clinical practice particularly in the field of epilepsy of several automatic spike detectors are combined.
surgery and functional brain mapping. However, under- This is especially true in the low signal-to-noise ratio
utilization and misunderstanding of the clinical applica- conditions. To this end we propose a novel biomimetic
tions of MEG is a challenge to more widespread use of approach for automatic spike detection based on a
this technology. A fundamental understanding of the constrained mixed spline machinery that we dub as fast
neurophysiology and physics of MEG is discussed in parametric curve matching (FPCM).Approach. Using
this article as well as practical issues related to imple- the peak-wave shape parametrization, the constrained
mentation, analysis, and clinical applications. The future parametric morphological model is constructed and
convolved with the observed multichannel data to
efficiently determine mixed spline parameters corre-
sponding to each time-point in the dataset. Then the

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