Page 150 - MEGIN Book Of Abstracts - 2023

Combined electrophysiological and morphological cies (strongest in MEG), which was eminent in the joint
phenotypes in patients with genetic generalized EEG/MEG analysis. EEG showed weaker connectivity dif-
epilepsy and their healthy siblings (2022) ferences in higher frequencies, possibly related to drug
effects. The inclusion of cortical thickness reinforced
Stier, Christina; Loose, Markus; Kotikalapudi, Raviteja; group differences in connectivity and power. Siblings
Elshahabi, Adham; Li Hegner, Yiwen; Marquetand, (n = 18) had functional and structural patterns interme-
Justus; Braun, Christoph; Lerche, Holger; Focke, Niels K diate between those of patients and controls.

Department of Neurology and Epileptology, Hertie Institute SIGNIFICANCE EEG detected increased connectivity
for Clinical Brain Research, University of Tübingen, Tübingen, and power in GGE similar to MEG, but with different
Germany; Clinic of Neurology, University Medical Center spectral sensitivity, highlighting the importance of the-
Göttingen, Göttingen, Germany; Institute of Psychology, Uni- ta and beta oscillations. Cortical thickness reductions in
versity of Bern, Bern, Switzerland; Department of Neurology, GGE corresponded to functional imaging patterns. Our
University Hospital Zurich, Zurich, Switzerland; Department multimodal approach extends the understanding of
of Neural Dynamics and Magnetoencephalography, Hertie the resting state in GGE and points to genetic under-
Institute for Clinical Brain Research, University of Tübingen, pinnings of the imaging markers studied, providing
Tübingen, Germany; Center for Mind/Brain Sciences, Univer- new insights into the causes and consequences of
sity of Trento, Rovereto, Italy epilepsy.

OBJECTIVE Genetic generalized epilepsy (GGE) is char- Keywords: cortical thickness, endophenotypes, interictal,
acterized by aberrant neuronal dynamics and subtle oscillations, resting state
structural alterations. We evaluated whether a com-
bination of magnetic and electrical neuronal signals Epilepsia (2022), Vol. 63, No. 7 (35416282) (1 citation)
and cortical thickness would provide complementary
information about network pathology in GGE. We also
investigated whether these imaging phenotypes were Connectomic Profiles and Cognitive Trajectories
present in healthy siblings of the patients to test for After Epilepsy Surgery in Children (2022)
genetic influence.
Arski, Olivia N; Martire, Daniel J; Young, Julia M; Wong,
METHODS In this cross-sectional study, we analyzed Simeon M; Suresh, Hrishikesh; Kerr, Elizabeth N; Ochi,
5 min of resting state data acquired using electroen- Ayako; Otsubo, Hiroshi; Sharma, Roy; Widjaja, Elysa;
cephalography (EEG) and magnetoencephalography Snead, O Carter; Jain, Puneet; Donner, Elizabeth J;
(MEG) in patients, their siblings, and controls, matched Smith, Mary Lou; Ibrahim, George M
for age and sex. We computed source-reconstructed
power and connectivity in six frequency bands (1- From the Program in Neuroscience and Mental Health
40 Hz) and cortical thickness (derived from magnetic (O.N.A., D.J.M., J.M.Y., S.M.W., M.L.S., G.M.I.), Hospital for Sick
resonance imaging). Group differences were assessed Children Research Institute; Institute of Medical Science
using permutation analysis of linear models for each (O.N.A., G.M.I.), University of Toronto; Department of Psychol-
modality separately and jointly for all modalities using ogy (J.M.Y., E.N.K., M.L.S.), Hospital for Sick Children, University
a nonparametric combination. of Toronto; Institute of Biomaterials and Biomedical Engineer-
ing (S.M.W., G.M.I.), University of Toronto; Division of Neuro-
RESULTS Patients with GGE (n = 23) had higher power surgery (H.S., G.M.I.), Hospital for Sick Children, Department
than controls (n = 35) in all frequencies, with a more of Surgery, University of Toronto; Division of Neurology (A.O.,
posterior focus in MEG than EEG. Connectivity was also H.O., R.S., O.C.S., P.J., E.J.D.) and Diagnostic Imaging (E.W.),
increased, particularly in frontotemporal and central re- Hospital for Sick Children, University of Toronto; and Depart-
gions in theta (strongest in EEG) and low beta frequen- ment of Psychology (M.L.S.), University of Toronto Missis-

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