Page 151 - MEGIN Book Of Abstracts - 2023

sauga, Ontario, Canada; From the Program in Neuroscience ates, which included changes in rote verbal memory
and Mental Health (O.N.A., D.J.M., J.M.Y., S.M.W., M.L.S., G.M.I.), (n = 41, p = 0.01, σ[2] = 0.38), narrative/verbal memory
Hospital for Sick Children Research Institute; Institute of Medi- (n = 57, p = 0.00, σ[2] = 0.52), visual memory (n = 51, p
cal Science (O.N.A., G.M.I.), University of Toronto; Department = 0.00, σ[2] = 0.43), working memory (n = 44, p = 0.00,
of Psychology (J.M.Y., E.N.K., M.L.S.), Hospital for Sick Children, σ[2] = 0.52), and overall intellectual function (n = 59, p
University of Toronto; Institute of Biomaterials and Biomedi- = 0.00, σ[2] = 0.55). Children with more diffuse, bilateral
cal Engineering (S.M.W., G.M.I.), University of Toronto; Division intrinsic connectivity across several frequency bands
of Neurosurgery (H.S., G.M.I.), Hospital for Sick Children, De- showed lower scores on all neuropsychological assess-
partment of Surgery, University of Toronto; Division of Neurol- ments but demonstrated a greater propensity for gains
ogy (A.O., H.O., R.S., O.C.S., P.J., E.J.D.) and Diagnostic Imaging after resective surgery.
(E.W.), Hospital for Sick Children, University of Toronto; and
Department of Psychology (M.L.S.), University of Toronto Mis- DISCUSSION Here, we report that connectomes
sissauga, Ontario, Canada. [email protected] characterized by diffuse connectivity, reminiscent of
developmentally immature networks, are associated
BACKGROUND AND OBJECTIVES Neurocognitive with lower preoperative cognition and postoperative
outcomes after surgery for temporal lobe epilepsy in cognitive improvement. These findings provide a po-
childhood are variable. Postoperative changes are not tential means to understand neurocognitive function
directly predicted by seizure freedom, and associations in children with temporal lobe epilepsy and expected
between epilepsy, neuropsychological function, and changes postoperatively.
developing neural networks are poorly understood.
Here, we leveraged whole-brain connectomic profiling Neurology (2022), Vol. 98, No. 22 (35410904) (0 citations)
in magnetoencephalography (MEG) to retrospectively
study associations between brain connectivity and
neuropsychological function in children with temporal Utility of magnetoencephalography combined
lobe epilepsy undergoing resective surgery. with stereo-electroencephalography in resective
epilepsy surgery: A 2-year follow-up (2022)
METHODS Clinical and MEG data were retrospec-
tively analyzed for children who underwent temporal Zhang, Chao; Liu, Wei; Zhang, Jing; Zhang, Xiaoxiao;
lobe epilepsy surgery at the Hospital for Sick Children Huang, Peng; Sun, Bomin; Zhan, Shikun; Cao, Chunyan
from 2000 to 2021. Resting-state connectomes were
constructed from neuromagnetic oscillations via the Department of Neurosurgery, Ruijin Hospital, Shanghai
weighted-phase lag index. Using a partial least-squares Jiao Tong University School of Medicine Shanghai, Shang-
(PLS) approach, we assessed multidimensional associa- hai, China; Department of Neurosurgery, Ruijin Hospital,
tions between patient connectomes, neuropsychologi- Shanghai Jiao Tong University School of Medicine Shanghai,
cal scores, and clinical covariates. Bootstrap resampling Shanghai, China. Electronic address: [email protected];
statistics were performed to assess statistical signifi- Department of Neurosurgery, Ruijin Hospital, Shanghai Jiao
cance. Tong University School of Medicine Shanghai, Shanghai,
China. Electronic address: [email protected]
RESULTS A total of 133 medical records were reviewed,
and 5 PLS analyses were performed. Each PLS analysis PURPOSE Precise and accurate implantation of stereo-
probed a particular neuropsychological domain and electroencephalography (SEEG) electrodes is critical
the associations between its baseline and postopera- for the localization of the seizure onset zone (SOZ),
tive scores and the connectomic data. In each PLS which plays a leading role in the prognosis of resective
analysis, a significant latent variable was identified, epilepsy surgery. Magnetoencephalography (MEG) is
representing a specific percentage of the variance in a noninvasive technique which can delineate the epi-
the data and relating neural networks to clinical covari- lepsy focus by visualizing interictal spikes into dipole

 ontents  Index 130
C