Page 149 - MEGIN Book Of Abstracts - 2023

logical predicates that directly map to verbalized text- Brain Disorders, Beijing, China. Electronic address: linhua@
book like descriptions of the expected interictal event ccmu.edu.cn; Department of Neurology, Xuanwu Hospi-
morphology allow us to accomplish the spike detection tal, Clinical Center for Epilepsy, Capital Medical University,
task.Main results. The results of simulations mimick- Chinese Institute for Brain Disorders, Beijing, China. Electronic
ing typical low SNR scenarios show the robustness address: [email protected]
and high receiver operating characteristic AUC values
of the FPCM method as compared to the spike detec- OBJECTIVES To investigate the effects of low-frequen-
tion performed using more conventional approaches cy repetitive transcranial magnetic stimulation (rTMS)
such as wavelet decomposition, template matching on patients with benign epilepsy with centrotemporal
or simple amplitude thresholding. Applied to the real spikes (BECTS).
MEG and EEG data from the human patients and to rat
ECoG data, the FPCM technique demonstrates reliable METHODS In this open pilot study, we enrolled four
detection of the interictal events and localization of BECTS patients who had frequent seizures (at least 3
epileptogenic zones concordant with independent seizures during the 3-month baseline). After localizing
conclusions made by the epileptologist.Significance. sources of interictal epileptiform discharges (IEDs) with
Since the FPCM is computationally light, tolerant to magnetoencephalography, IEDs-source-rTMS (1 Hz)
high amplitude artifacts and flexible to accommodate with 500 pulses at 90% of resting motor threshold was
verbalized descriptions of an arbitrary target morphol- applied for 10 weekdays in each patient. The primary
ogy, it is likely to complement the existing arsenal of outcome measure was the seizure-reduction rate after
means for analysis of noisy interictal datasets. rTMS. Other outcome measures were the spike-wave
index (SWI), behavioral evaluation, and adverse effects.
Keywords: EEG, MEG, automatic detection, epilepsy,
interictal spikes RESULTS All four patients received at least 3 months
seizure-free after rTMS. Compared with baseline, SWI
Journal of neural engineering (2022), Vol. 19, No. 3 decreased significantly after rTMS in three patients
(35439749) (0 citations) (patient 1, 3 and 4) (P = .002, P = .007, and P < .001, re-
spectively). Attention deficit identified in two patients
in baseline recovered to the normal range after rTMS.
Repetitive transcranial magnetic stimulation to No adverse effect was observed.
treat benign epilepsy with centrotemporal spikes
(2022) DISCUSSION Our preliminary observation provides a
promising approach to reducing clinical seizures for
Jin, Guangyuan; Chen, Jia; Du, Jialin; He, Liu; Qi, Lei; Wu, BECTS with frequent seizures. Of importance, our data
Di; Wang, Yuping; Lin, Hua; Ren, Liankun may provide a potentially novel method for the high
prevalence of behavioral problems in BECTS patients
Department of Neurology, Xuanwu Hospital, Clinical Center via decreasing cortical hyperexcitability.
for Epilepsy, Capital Medical University, Chinese Institute for
Brain Disorders, Beijing, China; Department of Pharmacy Keywords: Benign epilepsy with centrotemporal spikes,
Phase I Clinical Trial Center, Xuanwu Hospital, Clinical Center Electroencephalogram, Epilepsy, Neuromodulation, Re-
for Epilepsy, Capital Medical University, Chinese Institute for petitive transcranial magnetic stimulation
Brain Disorders, Beijing, China; Department of Functional
Neurosurgery, Beijing Institute of Functional Neurosurgery, Brain stimulation (2022), Vol. 15, No. 3 (35427811) (1
Xuanwu Hospital, Clinical Center for Epilepsy, Capital Medical citation)
University, Chinese Institute for Brain Disorders, Beijing, China;
Department of Neurology, Xuanwu Hospital, Clinical Center
for Epilepsy, Capital Medical University, Chinese Institute for

 ontents  Index 128
C