Page 145 - MEGIN Book Of Abstracts - 2023

Prognostic value of high-frequency oscillations CONCLUSIONS Intracranial electrodes are essential to
combined with multimodal imaging methods for detect regions which generate ripples and to remove
epilepsy surgery (2022) these areas which indicate good surgical outcome for
medically intractable epilepsy. With the assistance of
Yan, Xiaoming; Yin, Fangzhao; Xu, Cuiping; Yu, Tao; Li, presurgical noninvasive imaging examinations, PET and
Xiaonan; Wang, Wei; Zhang, Xi; Ma, Kai; Zhang, Guojun MEG, for example, the SEEG electrodes would identify
epileptogenic regions more effectively.
Beijing Institute of Functional Neurosurgery, Xuanwu Hospi-
tal, Capital Medical University, Beijing 100053, China; Bioland Chinese medical journal (2022), Vol. 135, No. 9 (35773966)
Laboratory Guangzhou Regenerative Medicine and Health (0 citations)
Guangdong Laboratory, Guangzhou, Guangdong 510005,
China
Retrospective comparison of motor and
BACKGROUND The combination of high-frequency somatosensory MEG mapping-Considerations for
oscillations (HFOs) with single-mode imaging methods better clinical applications (2022)
has been proved useful in identifying epileptogenic
zones, whereas few studies have examined HFOs Spooner, Rachel K; Madhavan, Deepak; Aizenberg,
combined with multimodal imaging methods. The Michele R; Wilson, Tony W
aim of this study was to evaluate the prognostic value
of ripples, an HFO subtype with a frequency of 80 to Institute for Human Neuroscience, Boys Town National
200 Hz is combined with multimodal imaging methods Research Hospital, Omaha, NE, USA; College of Medicine, Uni-
in predicting epilepsy surgery outcome. versity of Nebraska Medical Center, Omaha, NE, USA; Institute
of Clinical Neuroscience and Medical Psychology, Heinrich-
METHODS HFOs were analyzed in 21 consecutive Heine University, Düsseldorf, Germany. Electronic address:
medically refractory epilepsy patients who underwent [email protected]; Institute for
epilepsy surgery. All patients underwent positron emis- Human Neuroscience, Boys Town National Research Hospital,
sion tomography (PET) and deep electrode implanta- Omaha, NE, USA; College of Medicine, University of Nebraska
tion for stereo-electroencephalography (SEEG); 11 Medical Center, Omaha, NE, USA; Department of Pharmacol-
patients underwent magnetoencephalography (MEG). ogy & Neuroscience, Creighton University, Omaha, NE, USA
Sensitivity, specificity, positive predictive value, nega-
tive predictive value, and accuracy in predicting surgi- ABSTRACT While magnetoencephalography (MEG) has
cal outcome were calculated for ripples combined with proven to be a valuable and reliable tool for presurgical
PET, MEG, both PET and MEG, and PET combined with functional mapping of eloquent cortices for at least two
MEG. Kaplan-Meier survival analyses were conducted in decades, widespread use of this technique by clinicians
each group to estimate prognostic value. has remained elusive. This modest application may be
attributable, at least in part, to misunderstandings re-
RESULTS The study included 13 men and 8 women. garding the success rate of such mapping procedures,
Accuracy for ripples, PET, and MEG alone in predicting as well as the primary sources contributing to mapping
surgical outcome was 42.9%, 42.9%, and 81.8%, re- failures. To address this, we conducted a retrospective
spectively. Accuracy for ripples combined with PET and comparison of sensorimotor functional mapping suc-
MEG was the highest. Resection of regions identified by cess rates in 141 patients with epilepsy and 75 tumor
ripples, MEG dipoles, and combined PET findings was patients from the Center for MEG in Omaha, NE. Neuro-
significantly associated with better surgical outcome (P surgical candidates either completed motor mapping
< 0.05). (i.e., finger tapping paradigm), somatosensory mapping
(i.e., peripheral stimulation paradigm), or both motor
and somatosensory protocols during MEG. All MEG

 ontents  Index 124
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