Page 133 - MEGIN Book Of Abstracts - 2023

Epilepsy

Neuroimaging in Adults and Children With Epilepsy ent. Patients with an identified lesion on MRI have a
(2023) 2.5-fold improved chance of achieving seizure freedom
with epilepsy surgery compared with those without
Passaro, Erasmo A a lesion. This clinical-radiographic integration is
essential to accurate classification, localization, deter-
OBJECTIVE This article discusses the fundamental mination of long-term prognosis for seizure control,
importance of optimal epilepsy imaging using the In- and identification of candidates for epilepsy surgery to
ternational League Against Epilepsy-endorsed Harmo- reduce seizure burden or attain seizure freedom.
nized Neuroimaging of Epilepsy Structural Sequences
(HARNESS) protocol and the use of multimodality imag- Continuum (Minneapolis, Minn.) (2023), Vol. 29, No. 1
ing in the evaluation of patients with drug-resistant (36795875) (0 citations)
epilepsy. It outlines a methodical approach to evaluat-
ing these images, particularly in the context of clinical
information. Comparison of beamformer and ICA for dynamic
connectivity analysis: A simultaneous MEG-SEEG
LATEST DEVELOPMENTS Epilepsy imaging is rapidly study (2023)
evolving, and a high-resolution epilepsy protocol MRI
is essential in evaluating newly diagnosed, chronic, Coelli, Stefania; Medina Villalon, Samuel; Bonini,
and drug-resistant epilepsy. The article reviews the Francesca; Velmurugan, Jayabal; López-Madrona, Víctor
spectrum of relevant MRI findings in epilepsy and their J; Carron, Romain; Bartolomei, Fabrice; Badier, Jean-
clinical significance. Integrating multimodality imaging Michel; Bénar, Christian-G
is a powerful tool in the presurgical evaluation of epi-
lepsy, particularly in "MRI-negative" cases. For example, Department of Electronics, Information and Bioengineering,
correlation of clinical phenomenology, video-EEG with Politecnico di Milano, Milano, Italy; Aix Marseille University,
positron emission tomography (PET), ictal subtraction INSERM, INS, Inst Neurosci Syst, Marseille, France; APHM,
single-photon emission computerized tomography Timone Hospital, Epileptology and Cerebral Rythmology,
(SPECT), magnetoencephalography (MEG), functional Marseille, France; Aix Marseille University, INSERM, INS, Inst
MRI, and advanced neuroimaging such as MRI texture Neurosci Syst, Marseille, France; APHM, Timone Hospital,
analysis and voxel-based morphometry enhances the Functional and Stereotactic Neurosurgery, Marseille, France;
identification of subtle cortical lesions such as focal Aix Marseille University, INSERM, INS, Inst Neurosci Syst, Mar-
cortical dysplasias to optimize epilepsy localization and seille, France. Electronic address: [email protected]
selection of optimal surgical candidates.
ABSTRACT Magnetoencephalography (MEG) is a pow-
ESSENTIAL POINTS The neurologist has a unique erful tool for estimating brain connectivity with both
role in understanding the clinical history and seizure good spatial and temporal resolution. It is particularly
phenomenology, which are the cornerstones of neuro- helpful in epilepsy to characterize non-invasively the
anatomic localization. When integrated with advanced epileptic networks. However, using MEG to map brain
neuroimaging, the clinical context has a profound networks requires solving a difficult inverse problem
impact on identifying subtle MRI lesions or finding the that introduces uncertainty in the activity localiza-
"epileptogenic" lesion when multiple lesions are pres- tion and connectivity measures. Our goal here was

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